Mefenamic acid
Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Mefenamic acid is marketed in the USA as Ponstel.
Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis. There is also evidence that supports the use of mefenamic acid for perimenstrual migraine headache prophylaxis, with treatment starting 2 days prior to the onset of flow or 1 day prior to the expected onset of the headache and continuing for the duration of menstruation.[1]
Since hepatic metabolism plays a significant role in mefenamic acid elimination, patients with known liver deficiency may be prescribed lower doses. Kidney deficiency may also cause accumulation of the drug and its metabolites in the excretory system. Therefore patients suffering from renal conditions should not be prescribed mefenamic acid.
| Brand Names |
|---|
| Mefalth, Mefalth T, Ponstel, Ponstan, Ponstal, Parkemed, Mafepain, Mefamed, Mephadolor, Meftal, Dyfenamic, Potarlon, Dolfenal, Meyerdonal, Alfoxan, Fenagesic, Spiralgin. |
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Side effects
Known mild side effects of mefenamic acid include headaches, nervousness and vomiting. Serious side effects may include diarrhea, hematemesis (vomiting blood), haematuria (blood in urine), blurred vision, skin rash, itching and swelling, sore throat and fever. It is advised to consult a doctor immediately if these symptoms appear while taking this medication.
Mefenamic acid is recommended to be taken with food.[2]
Overdose
Overdose can lead to a range of symptoms including convulsions, nausea, vomiting, vomiting blood, shallow breathing, coma. Onset of symptoms is usually between 30 minutes and 4 hours, but signs of renal failure may appear several days after an overdose. Seek medical attention immediately in the case of overdose. The lethal dose can be as low as 2.5g.
Synthesis
Analogous to fenamic acid, this compound may be synthesized from 2-chlorobenzoic acid and 2,3-dimethylaniline.[3]
Mefenamic acid From Wikipedia, the free encyclopediaJump to: navigation, search Mefenamic acidSystematic (IUPAC) name2-(2,3-dimethylphenyl)aminobenzoic acidClinical dataTrade names PonstelAHFS/Drugs.com monographMedlinePlus a681028Pregnancy cat. C (Australia, United States)Legal status ℞-only (U.S.), POM in UKRoutes OralPharmacokinetic dataBioavailability 90%Protein binding 90%Metabolism Hepatic (CYP2C9)Half-life 2 hoursExcretion Renal and fecalIdentifiersCAS number 61-68-7 YATC code M01AG01PubChem CID 4044DrugBank APRD00730ChemSpider 3904 YUNII 367589PJ2C YKEGG D00151 YChEMBL CHEMBL686 YChemical dataFormula C15H15NO2Mol. mass 241.285 g/molSMILES eMolecules & PubChemInChI[show]InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18) YKey:HYYBABOKPJLUIN-UHFFFAOYSA-N Y N (what is this?) (verify)Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Mefenamic acid is marketed in the USA as Ponstel.Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis. There is also evidence that supports the use of mefenamic acid for perimenstrual migraine headache prophylaxis, with treatment starting 2 days prior to the onset of flow or 1 day prior to the expected onset of the headache and continuing for the duration of menstruation.[1]Since hepatic metabolism plays a significant role in mefenamic acid elimination, patients with known liver deficiency may be prescribed lower doses. Kidney deficiency may also cause accumulation of the drug and its metabolites in the excretory system. Therefore patients suffering from renal conditions should not be prescribed mefenamic acid.Brand NamesMefalth, Mefalth T, Ponstel, Ponstan, Ponstal, Parkemed, Mafepain, Mefamed, Mephadolor, Meftal, Dyfenamic, Potarlon, Dolfenal, Meyerdonal, Alfoxan, Fenagesic, Spiralgin.Contents [hide]1
http://en.wikipedia.org/wiki/mefenamic_acid
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